TAP1 antibody (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP)) (AA 765-794)

Details for Product anti-TAP1 Antibody No. ABIN390185, Supplier: Log in to see
Antigen
  • ABC17
  • ABCB2
  • APT1
  • D6S114E
  • PSF-1
  • PSF1
  • RING4
  • TAP1*0102N
  • TAP1N
  • abc17
  • abcb2
  • apt1
  • psf1
  • ring4
  • tap1a
  • tap1n
  • Abcb2
  • Ham-1
  • Ham1
  • MTP1
  • TAP
  • Tap-1
  • Y3
  • Cim
  • transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  • TAP1
  • tap1
  • Tap1
Alternatives
anti-Human TAP1 antibody for ELISA
Epitope
AA 765-794, C-Term
26
16
6
4
4
4
3
3
2
1
1
1
1
1
Reactivity
Human
95
22
22
1
1
1
1
1
1
Host
Rabbit
68
16
11
Clonality (Clone)
Polyclonal ()
Conjugate
This TAP1 antibody is un-conjugated
7
5
5
4
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
52
30
26
18
13
13
8
7
5
3
1
1
Options
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Immunogen This TAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-794 AA from the C-terminal region of human TAP1.
Clone RB1815-1816
Isotype Ig
Specificity This TAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773~802 amino acids from the C-terminal region of human TAP1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TAP1 (TAP1 Antibody Abstract)
Background TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. TAP is also inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP is down-regulated by human Epstein-barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. TAP1 and TAP2 form a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP, inducible by interferon gamma, belongs to the ABC transporter family, MDR subfamily.
Molecular Weight 80964 DA
Gene ID 6890
UniProt Q96CP4
Research Area Cell Structure
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes IHC (p) = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-TAP1 antibody (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP)) (AA 765-794) (ABIN390185) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-TAP1 antibody (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP)) (AA 765-794) (ABIN390185) TAP1 Antibody (I795) (ABIN390185) western blot analysis in Jurkat cell line lysates (...
Background publications Lajoie, Zijenah, Faucher, Ward, Roger: "Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases." in: Human immunology, Vol. 64, Issue 8, pp. 823-9, 2003 (PubMed).

Gaudet, Wiley: "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing." in: The EMBO journal, Vol. 20, Issue 17, pp. 4964-72, 2001 (PubMed).

Tang, Freedman, Allen, Karita, Musonda, Braga, Margolick, Kaslow: "TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies." in: Human immunology, Vol. 62, Issue 3, pp. 256-68, 2001 (PubMed).

Hewitt, Gupta, Lehner: "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP." in: The EMBO journal, Vol. 20, Issue 3, pp. 387-96, 2001 (PubMed).

Bennett, Bennink, Yewdell, Brodsky: "Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5049-52, 1999 (PubMed).