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Amyloid beta (A4) Precursor Protein (APP) (AA 29-61), (N-Term) antibody

Details for Product No. ABIN390282, Supplier: Login to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human Amyloid beta (A4) Precursor Protein antibody for Enzyme Immunoassay
Epitope
AA 29-61, N-Term
122
108
52
35
25
20
19
17
17
15
15
14
14
14
13
11
10
8
8
8
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
823
308
277
41
11
9
8
8
6
3
2
2
1
1
1
1
Host
Rabbit
579
223
50
3
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
48
37
35
17
13
13
13
13
13
13
13
13
12
11
11
2
2
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
563
316
231
149
147
75
57
33
28
20
15
10
9
8
6
3
2
2
2
2
1
Supplier
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Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-61 AA from the N-terminal region of human APP.
Clone RB5012
Isotype Ig
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human APP.
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name APP (APP Antibody Abstract)
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Alzheimer's disease amyloid A4 protein homolog , Soluble APP-beta, CTF-alpha, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, Gamma-CTF(59), Gamma-secretase C-terminal fragment 59), Gamma-CTF(57), (Gamma-secretase C-terminal fra
Molecular Weight 86943 DA
Gene ID 351
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 29-61), (N-Term) antibody (ABIN390282) Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (A...
Immunohistochemistry (IHC) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 29-61), (N-Term) antibody (ABIN390282) Formalin-fixed and paraffin-embedded human brain with APP Antibody (N-term), which wa...
Flow Cytometry (FACS) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 29-61), (N-Term) antibody (ABIN390282) Flow cytometric analysis of HepG2 cells using APP Antibody (N-term)(bottom histogram)...
Background publications Zhou, Su, Li et al.: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Kim, Kim, Lee et al.: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

Murakami, Irie, Morimoto et al.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).