Amyloid beta (A4) Precursor Protein (APP) (N-Term), (AA 29-61) antibody

Details for Product No. ABIN390282
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Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2 show less
Epitope
N-Term, AA 29-61
(99), (69), (33), (31), (19), (13), (13), (10), (8), (7), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(648), (356), (290), (212), (202), (197), (192), (71), (13), (12), (4), (2), (2), (1), (1)
Host
Rabbit
(458), (199), (41), (6), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(24), (20), (18), (17), (17), (17), (17), (17), (17), (17), (17), (4), (4), (4), (4), (4), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(434), (258), (169), (164), (137), (68), (44), (42), (24), (18), (7), (4), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN390282
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-61 AA from the N-terminal region of human APP.
Clone RB5012
Isotype Ig
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human APP.
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name APP
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Alzheimer's disease amyloid A4 protein homolog , Soluble APP-beta, CTF-alpha, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, Gamma-CTF(59), Gamma-secretase C-terminal fragment 59), Gamma-CTF(57), (Gamma-secretase C-terminal fra
Molecular Weight 86943 DA
Gene ID 351
UniProt A4_HUMAN
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term), (AA 29-61) antibody Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term) (ABIN390282). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) (Origene Technologies).
anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term), (AA 29-61) antibody (2) Formalin-fixed and paraffin-embedded human brain with APP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term), (AA 29-61) antibody (3) Flow cytometric analysis of HepG2 cells using APP Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Murakami, Irie, Morimoto et al.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee et al.: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

Zhou, Su, Li et al.: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Hosts (458), (199), (41), (6), (1)
Reactivities (648), (356), (290), (212), (202), (197), (192), (71), (13), (12), (4), (2), (2), (1), (1)
Applications (434), (258), (169), (164), (137), (68), (44), (42), (24), (18), (7), (4), (2), (1), (1), (1), (1)
Conjugates (24), (20), (18), (17), (17), (17), (17), (17), (17), (17), (17), (4), (4), (4), (4), (4), (2), (2)
Epitopes (99), (69), (33), (31), (19), (13), (13), (10), (8), (7), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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