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NFkB cRel (AA 586-619), (C-Term) antibody

Details for Product No. ABIN390316, Supplier: Log in to see
Antigen
  • NFkB
Epitope
AA 586-619, C-Term
25
20
12
5
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
94
40
14
1
1
1
Host
Rabbit
80
16
4
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Western Blotting (WB)
66
27
21
19
17
16
5
4
3
2
2
1
1
1
Supplier
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Immunogen This C-rel (NFkB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-619 AA from the C-terminal region of human C-rel (NFkB).
Clone RB8325
Isotype Ig
Specificity This C-rel (NFkB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590~619 amino acids from the C-terminal region of human C-rel (NFkB).
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name C-rel (NFkB)
Background Nuclear factor (NF)-kappa B is a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB regulates the expression of a wide variety of genes that involved in apoptosis, viral life cycle, tumorigenesis, autoimmune diseases and inflammation. NF-kB is a heterodimer of members of the rel family of proteins such as p50, p65, and c-rel. In most cells, inhibitory IkB proteins sequester NF-kB/Rel in the cytoplasm. Cellular stimulation precipitates degradation of IkB and modification of NF-kB/Rel proteins, permitting translocation of NF-kB/Rel (c-Rel and RelA) to the nucleus for action on target genes. The important role of c-Rel in B-cell development, growth, and survival has been intensively studied, as well as its function in differentiation and lymphopoiesis (particularly lymphoid cancer).
Synonyms: C-Rel proto-oncogene protein, C-Rel protein, REL,
Molecular Weight 68520 DA
Gene ID 5966
UniProt Q04864
Research Area Cell Signaling, Cancer, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-NFkB cRel (AA 586-619), (C-Term) antibody (ABIN390316) Western blot analysis of anti-C-rel (NFkB) Pab (ABIN390316)in Jurkat (left) and mouse...
Background publications Jain, Ma, Lopez-Granados, Means, Brady, Orange, Liu, Holland, Derry: "Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1593-602, 2004 (PubMed).

Phelps, Ghosh: "Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity." in: Oncogene, Vol. 23, Issue 6, pp. 1229-38, 2004 (PubMed).

Bernard, Gosselin, Monte, Vercamer, Bouali, Pourtier, Vandenbunder, Abbadie: "Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence." in: Cancer research, Vol. 64, Issue 2, pp. 472-81, 2004 (PubMed).