|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Interleukin 1 Receptor, Type I (IL1R1) (C-Term,Glu487) antibody
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal(E487) region of human IL1R.|
|Description||Other names: Interleukin-1 receptor-like 2 [Precursor], IL-1Rrp2, Interleukin-1 receptor-related protein 2, IL1R-rp2, IL1RL2, IL1RRP2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal(E487) region of human IL1R.|
|Molecular Weight||65405 DA|
Background: IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
|Application Notes||The suggested dilution is: ELISA1:1,000 Western blotting 1:50~100 Immunohistochemistry ~~ 1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Lovenberg, Crowe, Liu et al.: "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)." in: Journal of neuroimmunology, Vol. 70, Issue 2, pp. 113-22, 1996 (PubMed).
Torigoe, Ushio, Okura et al.: "Purification and characterization of the human interleukin-18 receptor." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25737-42, 1997 (PubMed).
Dale, Nicklin: "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q." in: Genomics, Vol. 57, Issue 1, pp. 177-9, 1999 (PubMed).
Debets, Timans, Homey et al.: "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1440-6, 2001 (PubMed).
|Hosts||Rat (17), Rabbit (16), Mouse (10), Hamster (7), Goat (1)|
|Reactivities||Mouse (Murine) (25), Human (23), Rat (Rattus) (3)|
|Applications||Western Blotting (WB) (32), ELISA (27), Immunoprecipitation (IP) (19), Immunohistochemistry (IHC) (13), Radioimmunoassay (RIA) (10), Flow Cytometry (FACS) (9), Functional Studies (Func) (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunocytochemistry (ICC) (2), Immunodiffusion (ID) (2), Immunofluorescence (IF) (2), Neutralization (Neut) (2)|
|Conjugates||Biotin (2), CF (1)|
|Epitopes||Extracellular Domain (7), C-Term (3), pTyr496 (2)|