Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (C-Term), (AA 75-104) antibody

Details for Product No. ABIN390364
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Antigen
Synonyms NACP, alphaSYN, PARK1, PARK4, PD1
Epitope
C-Term, AA 75-104
(40), (33), (27), (25), (25), (14), (12), (10), (7), (7), (7), (6), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(383), (165), (141), (92), (89), (78), (24), (24), (3), (1), (1)
Host
Rabbit
(280), (95), (15), (10), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(13), (11), (11), (8), (8), (8), (8), (8), (8), (8), (8)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(267), (114), (83), (80), (74), (66), (29), (22), (16), (6), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN390364
291.50 $
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Immunogen This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 AA from the C-terminal region of human SNCA.
Clone RB07369
Isotype Ig
Specificity This alpha Synuclein antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82~112 amino acids from the C-terminal region of human Alpha-synuclein that recognizes both NACP112 and NCAP140.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name alpha Synuclein
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP112) lacks an alternate in-frame segment, compared to variant NACP140, resulting in a shorter protein (isoform NACP112) that has a distinct C-terminus, compared to isoform NACP140. This antibody recognizes both NACP112 and NCAP140.
Synonyms: Alpha synuclein antibody, MGC110988 antibody, NACP antibody,Non A beta component of AD amyloid antibody, Non A4 component of amyloid precursor antibody, PARK 1 antibody, PARK 4 antibody, PARK1 antibody, PARK4 antibody, Parkinson disease familial 1 antibod
Molecular Weight 11372 DA
Gene ID 6622
NCBI Accession NP_009292
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (C-Term), (AA 75-104) antibody Western blot analysis of anti-Alpha-synuclein Pab (ABIN390364) in mouse brain tissue lysate. Alpha-synuclein (arrow) was detected using the purified polyclonal antibody.
anti-Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (C-Term), (AA 75-104) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

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