Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (C-Term), (AA 387-417) antibody

Details for Product No. ABIN390366
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Antigen
Synonyms Park, Prkn
Epitope
C-Term, AA 387-417
(13), (10), (8), (8), (6), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(106), (20), (17), (3), (3), (1), (1)
Host
Rabbit
(81), (21), (14)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(98), (60), (38), (24), (10), (10), (8), (6), (6), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN390366
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-417 AA from the C-terminal region of human Parkin.
Clone RB07373
Isotype Ig
Specificity This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395~425 amino acids from the C-terminal region of human Park2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Parkin
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
Synonyms: Parkin isoform 1, Parkin, E3 ubiquitin ligase, Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PRKN, Park2
Molecular Weight 51651 DA
Gene ID 5071
UniProt NP_004553
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50, FACS = 1:10-50, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (C-Term), (AA 387-417) antibody The anti-Parkin C-term Pab (ABIN390366) is used in Western blot to detect Parkin in mouse kidney tissue lysate.
anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (C-Term), (AA 387-417) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (C-Term), (AA 387-417) antibody (3) Formalin-fixed and paraffin-embedded human testis tissue reacted with PARK2 (Parkin) antibody (C-term) (ABIN390366), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

Hosts (81), (21), (14)
Reactivities (106), (20), (17), (3), (3), (1), (1)
Applications (98), (60), (38), (24), (10), (10), (8), (6), (6), (2), (2), (1)
Conjugates (2), (1), (1), (1), (1), (1)
Epitopes (13), (10), (8), (8), (6), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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