SNCA antibody (Synuclein, alpha) (AA 104-133)

Details for Product anti-SNCA Antibody No. ABIN390368, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Alternatives
anti-Human SNCA antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 104-133, C-Term
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Reactivity
Human, Mouse (Murine)
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Host
Rabbit
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Clonality (Clone)
Polyclonal ()
Conjugate
This SNCA antibody is un-conjugated
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Application
Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 AA from the C-terminal region of human SNCA.
Clone RB7377
Isotype Ig
Specificity This alpha Synuclein antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111~140 amino acids from the C-terminal region of human Alpha-synuclein that is specific for Alpha-synuclein isoform NACP140 not NACP112.
Predicted Reactivity Cow (Bovine),Pig (Porcine),Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name alpha Synuclein (SNCA Antibody Abstract)
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.
Synonyms: Alpha synuclein antibody, MGC110988 antibody, NACP antibody,Non A beta component of AD amyloid antibody, Non A4 component of amyloid precursor antibody, PARK 1 antibody, PARK 4 antibody, PARK1 antibody, PARK4 antibody, Parkinson disease familial 1 antibod
Molecular Weight 14460 DA
Gene ID 6622
NCBI Accession NP_000336
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Synuclein, alpha (SNCA) (AA 104-133), (C-Term) antibody (ABIN390368) Western blot analysis of anti-Alpha-synuclein Pab (ABIN390368) in mouse brain tissue ...
Background publications West, Kapatos, OFarrell, Gonzalez-de-Chavez, Chiu, Farrer, Maidment: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai, Philips, Montoya, Kock, Schüle, Klein, Shridhar, Roberts, Smith: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

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