G Protein-Coupled Receptor 37 (GPR37) (C-Term), (AA 217-246) antibody

Details for Product No. ABIN390380
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Antigen
Synonyms AI848630, Pael-R, Ednrbl
Epitope
C-Term, AA 217-246
(2), (2), (1), (1)
Reactivity
Human
(3), (2)
Host
Rabbit
(3)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(3), (3)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN390380
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Immunogen This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 AA from the C-terminal region of human Pael-R (GPR37).
Clone RB07397
Isotype Ig
Specificity This GPR37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224~254 amino acids from the C-terminal region of human Pael-R (GPR37).
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Pael-R (GPR37)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons, coexpression of Parkin degrades Pael-R and suppresses its toxicity.
Synonyms: Endothelin B receptor-like protein-1, ETBR-LP-1, Parkin-associated endothelin receptor-like receptor, endothelin receptor type B-like, PAELR, G protein-coupled receptor 37, GPR37
Molecular Weight 67114 DA
Gene ID 2861
NCBI Accession NP_005293
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-G Protein-Coupled Receptor 37 (GPR37) (C-Term), (AA 217-246) antibody Western blot analysis of anti-Pael-R (GPR37) Pab (ABIN390380) in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified polyclonal antibody.
anti-G Protein-Coupled Receptor 37 (GPR37) (C-Term), (AA 217-246) antibody (2) Western blot analysis of anti-Pael-R (GPR37) Antibody (C-term)(ABIN390380) in K562 cell line lysates (35 µg/lane). Pael-R (arrow) was detected using the purified polyclonal antibody.
anti-G Protein-Coupled Receptor 37 (GPR37) (C-Term), (AA 217-246) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Marazziti, Golini, Gallo et al.: "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library." in: Genomics, Vol. 45, Issue 1, pp. 68-77, 1997 (PubMed).

Imai, Soda, Inoue et al.: "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin." in: Cell, Vol. 105, Issue 7, pp. 891-902, 2001 (PubMed).

Yang, Nishimura, Imai et al.: "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila." in: Neuron, Vol. 37, Issue 6, pp. 911-24, 2003 (PubMed).

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