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Details for Product No. ABIN390563

Voltage-Dependent Anion Channel 1 (VDAC1) (N-Term), (AA 1-30) antibody

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Antigen
Synonyms PORIN, VDAC-1, Vdac5, AL033343, fa13f11, zgc:85830, wu:fa13f11, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, vdac1, VDAC1
Epitope
»Alternatives N-Term, AA 1-30
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN390563
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human VDAC1.
Clone RB19920
Isotype Ig
Specificity This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human VDAC1.
Predicted Reactivity Cow (Bovine),Pig (Porcine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VDAC1
Background VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Synonyms: Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC, VDAC1
Molecular Weight 30773 DA
Gene ID 7416
UniProt P21796
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.33 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Hiller, Garces, Malia et al.: "Solution structure of the integral human membrane protein VDAC-1 in detergent micelles." in: Science (New York, N.Y.), Vol. 321, Issue 5893, pp. 1206-10, 2008 (PubMed).

Shoshan-Barmatz, Zakar, Rosenthal et al.: "Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase." in: Biochimica et biophysica acta, Vol. 1787, Issue 5, pp. 421-30, 2009 (PubMed).

Alternatives for antigen "Voltage-Dependent Anion Channel 1 (VDAC1)", type "Antibodies"
Hosts (43), (28)
Reactivities (65), (38), (38), (6), (6), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (69), (32), (26), (20), (14), (5), (2), (2), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (7), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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