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Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (N-Term) antibody

Antigen

Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4)
Synonyms TX, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II, Casp11, MGC124949, CASP4, CASP13, MGC137679
Binding Site
Alternatives

N-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN390682
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (N-Term) antibody

Additional Information
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Alternative name CASP4
Gene ID 837
UniProt P49662
Immunogen This CASP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37~66 amino acids from the N-terminal region of human CASP4.
Isotype Ig
Description Other names: Caspase-4, CASP-4, ICH-2 protease, TX protease, ICE(rel)-II, Caspase-4 subunit 1, Caspase-4 subunit 2, ICH2, CASP4
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity This CASP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37~66 amino acids from the N-terminal region of human CASP4.
Molecular Weight 43262 DA
Comments

Background: CASP4 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, it induces cell apoptosis.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Apoptosis/Necrosis
Restrictions For Research Use only

Publications
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Product Lakshmanan, Porter: "Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 )." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 12, pp. 8480-90, 2007 (PubMed).

Alternatives
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Alternatives for antigen "Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4)", type "Antibodies"
Hosts Rabbit (105), Rat (7), Mouse (6), Goat (4), Chicken (2)
Reactivities Human (83), Mouse (Murine) (65), Rat (Rattus) (47), Chicken (19), Zebrafish (18), Cow (Bovine) (4), Monkey (2), Cat (Feline) (1), Dog (Canine) (1)
Applications Western Blotting (WB) (90), ELISA (39), Immunofluorescence (IF) (33), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (25), Immunohistochemistry (IHC) (24), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Immunoprecipitation (IP) (4), Flow Cytometry (FACS) (3), Immunocytochemistry (ICC) (3), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (5), PE (4), FITC (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2)
Epitopes Middle Region (21), N-Term (16), Internal Region (8), C-Term (4), AA 1-89 (2), AA 85-101 (2), AA 119-133 (1), AA 202-217 (1), C-Term,AA 277-306 (1), Center (1), N-Term,AA 37-66 (1)