Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) (C-Term), (AA 737-763) antibody

Details for Product No. ABIN390869
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Antigen
Synonyms cb1055, hadha, im:7136067, wu:fa14c08, ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA, RGD1560655, C77020, Mtpa
Epitope
C-Term, AA 737-763
(8), (2), (1), (1), (1)
Reactivity
Human
(28), (16), (15), (12), (12)
Host
Rabbit
(28)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(19), (10), (9), (7), (4), (3), (2), (2)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN390869
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Immunogen This HADHA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-763 AA from the C-terminal region of human HADHA.
Clone RB20987
Isotype Ig
Specificity This HADHA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 734~763 amino acids from the C-terminal region of human HADHA.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HADHA
Background HADHA is the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities.
Synonyms: Trifunctional enzyme subunit alpha, mitochondrial, TP-alpha, 78 kDa gastrin-binding protein, Long-chain enoyl-CoA hydratase, Long chain 3-hydroxyacyl-CoA dehydrogenase, HADH, HADHA
Pathways: Fatty acid metabolism, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism, Biosynthesis of unsaturated fatty acids
Molecular Weight 83000 Da
Gene ID 3030
UniProt P40939
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) (C-Term), (AA 737-763) antibody Western blot analysis of HADHA Antibody (C-term) (ABIN390869) in A2058, A375, NCI-H460, Romas cell line lysates (35 µg/lane). HADHA (arrow) was detected using the purified polyclonal antibody.
anti-Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) (C-Term), (AA 737-763) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with HADHA Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) (C-Term), (AA 737-763) antibody (3) HADHA Antibody (C-term) (ABIN390869) flow cytometry analysis of Ramos cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Sims, Brackett, Powell et al.: "The molecular basis of pediatric long chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with maternal acute fatty liver of pregnancy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 3, pp. 841-5, 1995 (PubMed).

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