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Details for Product No. ABIN391034

LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258), (Center) antibody

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Antigen
Synonyms KPM, AV277261, AW228608, 4932411G09Rik
Epitope
»Alternatives AA 228-258, Center
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN391034
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-258 AA from the Central region of human LATS2.
Clone RB3032
Isotype Ig
Specificity This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195~224 amino acids from the center region of human LATS2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LATS2
Background LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Synonyms: Serine/threonine-protein kinase LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein, Warts-like kinase, KPM
Molecular Weight 115321 DA
Gene ID 26524
UniProt Q9P2X1
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

Alternatives for antigen "LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2)", type "Antibodies"
Hosts (43), (2)
Reactivities (42), (35), (24), (24), (24), (12), (12)
Applications (23), (20), (19), (9), (8), (3), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (2), (2), (1), (1), (1), (1), (1)
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