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Details for Product No. ABIN391055

AMPK Beta2 (PRKAB2) (N-Term), (AA 3-33) antibody

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Antigen
Epitope
N-Term, AA 3-33
Reactivity
Human, Mouse (Murine)
Host
Rabbit
Clonality (Clone) Polyclonal ()
Application
Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN391055
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This AMPK beta2 (PRKAB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 AA from the N-terminal region of human AMPK beta2 (PRKAB2).
Clone RB3183
Isotype Ig
Specificity This PRKAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human PRKAB2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Synonyms: 5'-AMP-activated protein kinase, beta-2 subunit, AMPK beta-2 chain
Molecular Weight 30302 DA
Gene ID 5565
UniProt NP_005390
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Thornton, Snowden, Carling: "Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12443-50, 1998 (PubMed).

Xu, Huang, Xu et al.: "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 26, pp. 15089-94, 2001 (PubMed).

Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

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