anti-PRKACB antibody (Protein Kinase, CAMP Dependent, Catalytic, beta) (AA 17-47)

Details for Product anti-PRKACB Antibody No. ABIN391057
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AA 17-47, N-Term
(19), (15), (8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(69), (21), (20), (1), (1), (1)
(65), (5)
Clonality (Clone)
Polyclonal ()
This PRKACB antibody is un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(50), (30), (18), (10), (7), (5), (3), (2)
Pubmed 3 references available
Quantity 400 μL
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Availability Please contact our customer support.
Immunogen This c-AMPProtein Kinase Catalytic subnunit antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 AA from the N-terminal region of human c-AMPProtein Kinase Catalytic subnunit.
Clone RB3882
Isotype Ig
Specificity This c-AMPProtein Kinase Catalytic subnunit Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25~54 amino acids from the N-terminal region of human PRKACB.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PKA C-beta (PRKACB) (PRKACB Antibody Abstract)
Background CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.
Synonyms: cAMP-dependent protein kinase, beta-catalytic subunit, PKA C-beta
UniProt P22694
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways AMPK Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PRKACB antibody (Protein Kinase, CAMP Dependent, Catalytic, beta) (AA 17-47) (ABIN391057) The anti-PRKACB Pab (ABIN391057) is used in Western blot to detect PRKACB in A375 cel...
Background publications Higuchi, Yamashita, Yoshikawa et al.: "PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts." in: The EMBO journal, Vol. 22, Issue 8, pp. 1790-800, 2003 (PubMed).

Wu, Mattioli, Morse et al.: "c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene." in: Oncogene, Vol. 21, Issue 51, pp. 7872-82, 2002 (PubMed).

Jiang, Tsien, Schultz et al.: "The effects of aging on gene expression in the hypothalamus and cortex of mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1930-4, 2001 (PubMed).

Catalog No. ABIN391057
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