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NIMA-Related Kinase 8 (NEK8) (AA 65-95), (N-Term) antibody

Details for Product No. ABIN391136, Supplier: Log in to see
Antigen
  • 4632401F23Rik
  • b2b1449Clo
  • jck
  • JCK
  • NEK12A
  • NPHP9
Epitope
AA 65-95, N-Term
34
16
15
2
2
1
1
Reactivity
Human
71
31
21
Host
Rabbit
77
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
6
6
6
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
62
42
11
10
4
3
2
1
Supplier
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Immunogen This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 AA from the N-terminal region of human NEK8.
Clone RB5456
Isotype Ig
Specificity This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73~103 amino acids from the N-terminal region of human NEK8.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name NEK8 (NEK8 Antibody Abstract)
Background NEK8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.
Synonyms: Serine/threonine-protein kinase Nek8, NimA-related protein kinase 8, NIMA-related kinase 12a, NEK12A
Molecular Weight 74806 DA
Gene ID 284086
UniProt Q86SG6
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-NIMA-Related Kinase 8 (NEK8) (AA 65-95), (N-Term) antibody (ABIN391136) The anti-NEK8 Pab (ABIN391136) is used in Western blot to detect NEK8 in A2058 cell l...
Background publications Valkova, Yunis, Mak et al.: "Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 7, pp. 1009-18, 2005 (PubMed).

Holland, Milne, Garka et al.: "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 16229-40, 2002 (PubMed).