NIMA-Related Kinase 8 (NEK8) (C-Term), (AA 573-604) antibody

Details for Product No. ABIN391137
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Antigen
Synonyms 4632401F23Rik, b2b1449Clo, jck, JCK, NEK12A, NPHP9
Epitope
C-Term, AA 573-604
(15), (8), (7), (1), (1), (1)
Reactivity
Human
(36), (23), (16), (11), (11), (11)
Host
Rabbit
(42), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(34), (21), (9), (5), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN391137
291.50 $
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Immunogen This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-604 AA from the C-terminal region of human NEK8.
Clone RB5458
Isotype Ig
Specificity This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 582~611 amino acids from the C-terminal region of human NEK8.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name NEK8
Background NEK8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.
Synonyms: Serine/threonine-protein kinase Nek8, NimA-related protein kinase 8, NIMA-related kinase 12a, NEK12A
Molecular Weight 74806 DA
Gene ID 284086
UniProt Q86SG6
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-NIMA-Related Kinase 8 (NEK8) (C-Term), (AA 573-604) antibody The anti-NEK8 Pab (ABIN391137) is used in Western blot to detect NEK8 in A2058 cell lysate.
Background publications Holland, Milne, Garka et al.: "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 16229-40, 2002 (PubMed).

Valkova, Yunis, Mak et al.: "Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 7, pp. 1009-18, 2005 (PubMed).

Validation Images
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