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Details for Product No. ABIN391146

Leucine-Rich Repeat Kinase 2 (LRRK2) (AA 878-909), (Leu893) antibody

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Antigen
Synonyms PARK8, RIPK7, ROCO2, AURA17, DARDARIN, Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, LRRK2
Epitope
»Alternatives AA 878-909, Leu893
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN391146
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 878-909 AA from human PARK8(LRRK2).
Clone RB7207
Isotype Ig
Specificity This PARK8 (LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide (10-30 aa in length) surrounding amino acid L893 of human LRRK2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PARK8 (LRRK2)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Synonyms: Park8, Leucine-rich repeat (LRR) kinase 2, Leucine-rich repeat kinase 2
Molecular Weight 280863 DA
Gene ID 120892
UniProt NP_940980
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Shen: "Protein kinases linked to the pathogenesis of Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 575-7, 2004 (PubMed).

Paisán-Ruíz, Jain, Evans et al.: "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 595-600, 2004 (PubMed).

Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).

Alternatives for antigen "Leucine-Rich Repeat Kinase 2 (LRRK2)", type "Antibodies"
Hosts (121), (49), (7), (4)
Reactivities (158), (91), (74), (40), (15), (13), (2)
Applications (144), (49), (47), (44), (38), (25), (20), (18), (17), (8), (2), (2), (1), (1), (1)
Conjugates (9), (9), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (20), (18), (18), (12), (12), (8), (6), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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