|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Activin A Receptor, Type IIA (ACVR2A) (N-Term) antibody
|Synonyms||ACVR2, ACTRII, Acvr2, ActrIIa, TactrII, rActR-II, ACVR2A, acvr2a, acvr2, actr2a, wu:fa02e10, actrii|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A.|
|Description||Other names: Activin receptor type-2A [Precursor], Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A.|
|Molecular Weight||57639 DA|
Background: ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle|
|Restrictions||For Research Use only|
Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).
Greenwald, Groppe, Gray et al.: "The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly." in: Molecular cell, Vol. 11, Issue 3, pp. 605-17, 2003 (PubMed).
Olaru, Mori, Yin et al.: "Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 12, pp. 1867-71, 2003 (PubMed).
|Hosts||Rabbit (12), Goat (4), Mouse (2)|
|Reactivities||Human (15), Mouse (Murine) (8), Rat (Rattus) (6)|
|Applications||Western Blotting (WB) (18), ELISA (13), Immunohistochemistry (IHC) (5), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunoprecipitation (IP) (2), Neutralization (Neut) (2)|
|Epitopes||N-Term (4), Extracellular Domain (3)|