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Lemur tyrosine Kinase 2 (LMTK2) (C-Term) antibody
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This LMTK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1243~1273 amino acids from the C-terminal region of human LTK2.|
|Description||Other names: Serine/threonine-protein kinase LMTK2 [Precursor], Lemur tyrosine kinase 2, Serine/threonine protein kinase KPI-2, Kinase/phosphatase/inhibitor 2, Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, hBREK, CDK5/p35-regulated kinase, CPRK, LMTK2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This LMTK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1243~1273 amino acids from the C-terminal region of human LTK2.|
|Molecular Weight||164927 DA|
Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western Blot~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Signaling, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure|
|Restrictions||For Research Use only|
|Western blot analysis of LTK2 (arrow) using rabbit polyclonal LMTK2 Antibody (C-term) (ABIN391209). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LTK2 gene (Lane 2) (Origene Technologies).|
Wang, Brautigan: "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49605-12, 2002 (PubMed).
Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).
Kesavapany, Lau, Ackerley et al.: "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 12, pp. 4975-83, 2003 (PubMed).
|Hosts||Rabbit (14), Goat (3), Mouse (2)|
|Reactivities||Human (20), Dog (Canine) (1), Mouse (Murine) (1), Rat (Rattus) (1)|
|Applications||ELISA (18), Western Blotting (WB) (16), Immunohistochemistry (IHC) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Dot Blot (DB) (2), Immunofluorescence (IF) (2), Immunocytochemistry (ICC) (1)|
|Epitopes||Internal Region (5), N-Term (2), C-Term (1), Center (1)|