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Details for Product No. ABIN391219

MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (N-Term), (AA 6-40) antibody

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Antigen
Synonyms MARK, Par-1c, Par1c, AW491150, B930025N23Rik, Emk3, mKIAA1477, mPar-1c, MGC80341, MARK1
Epitope
»Alternatives N-Term, AA 6-40
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN391219
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-40 AA from the N-terminal region of human MARK1.
Clone RB8545
Isotype Ig
Specificity This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16~45 amino acids from the N-terminal region of human MARK1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MARK1
Background MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
Molecular Weight 85000 DA
Gene ID 4139
UniProt Q2HIY1
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Drewes, Ebneth, Preuss et al.: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption." in: Cell, Vol. 89, Issue 2, pp. 297-308, 1997 (PubMed).

Alternatives for antigen "MAP/microtubule Affinity-Regulating Kinase 1 (MARK1)", type "Antibodies"
Hosts (29), (5)
Reactivities (29), (19), (6)
Applications (20), (14), (11), (3), (2), (1), (1)
Epitopes (9), (8), (5), (2), (2), (1), (1), (1)
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