Pantothenate Kinase 4 (PANK4) (N-Term) antibody

Antigen: Pantothenate Kinase 4 (PANK4)

Synonyms: FLJ10782, DKFZp547M242, Fang1, R75150, D030031I12Rik, MGC66285, MGC142618, DKFZp469B1320

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN391241

Additional Information

Alternative name: PANK4

Gene ID: 55229

UniProt: Q9NVE7

Immunogen: This PANK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45~75 amino acids from the N-terminal region of human PANK4.

Isotype: Ig

Description: Other names: Pantothenic acid kinase 4, hPanK4,

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PANK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45~75 amino acids from the N-terminal region of human PANK4.

Molecular Weight: 85991 DA

Comments:

Background: PANK4 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1,000 Western Blot~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of PANK4 Antibody (N-term) (ABIN391241) in mouse lung tissue lysates (35ug/lane). PANK4 (arrow) was detected using the purified Pab.

Publications

Product: Zhou, Westaway, Levinson et al.: "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome." in: Nature genetics, Vol. 28, Issue 4, pp. 345-9, 2001 (PubMed).