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PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 476-507)

Details for Product anti-PRKAA2 Antibody No. ABIN391306, Supplier: Login to see New
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Antigen
Synonyms ampk, ampk2, prkaa, prkaa1, PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, Ampk, Ampka2, 2310008I11Rik, A830082D05, AMPKalpha2, AMPKA2
Alternatives
Epitope
AA 476-507, C-Term
(45), (18), (16), (16), (16), (14), (13), (13), (13), (13), (6), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(235), (96), (79), (6), (4), (4), (2), (1), (1), (1), (1)
Host
Rabbit
(201), (25), (17), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
This PRKAA2 antibody is un-conjugated
(12), (12), (12), (8), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(175), (103), (62), (44), (26), (22), (16), (13), (6), (3), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 400 μL
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Immunogen This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-507 AA from the C-terminal region of human AMPK alpha2.
Clone RB2523
Isotype Ig
Specificity This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484~514 amino acids from the C-terminal region of human AMPK.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AMPK Alpha2 (PRKAA2 Antibody Abstract)
Background AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Synonyms: 5'-AMP-activated protein kinase, catalytic alpha-2 chain, AMPK alpha-2 chain
Molecular Weight 62319 DA
Gene ID 5563
UniProt P54646
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Pathways AMPK Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 476-507) (ABIN391306) Western blot analysis of anti-AMPK alpha2 C-term Pab (ABIN391306) in mouse heart tiss...
Background publications Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

Shaw, Kosmatka, Bardeesy et al.: "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3329-35, 2004 (PubMed).

Andersson, Filipsson, Abbott et al.: "AMP-activated protein kinase plays a role in the control of food intake." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12005-8, 2004 (PubMed).

Browne, Finn, Proud: "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12220-31, 2004 (PubMed).

Catalog No. ABIN391306
$324.50
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