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Details for Product No. ABIN391306

Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (C-Term), (AA 476-507) antibody

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Antigen
Synonyms AMPK, AMPK2, AMPKa2, PRKAA, Ampk, Ampka2, A830082D05, AMPKalpha2, 2310008I11Rik, AMPKA2, ampk, ampk2, prkaa, prkaa1, PRKAA2
Epitope
»Alternatives C-Term, AA 476-507
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN391306
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-507 AA from the C-terminal region of human AMPK alpha2.
Clone RB2523
Isotype Ig
Specificity This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484~514 amino acids from the C-terminal region of human AMPK.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AMPK Alpha2
Background AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Synonyms: 5'-AMP-activated protein kinase, catalytic alpha-2 chain, AMPK alpha-2 chain
Molecular Weight 62319 DA
Gene ID 5563
UniProt P54646
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Browne, Finn, Proud: "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12220-31, 2004 (PubMed).

Andersson, Filipsson, Abbott et al.: "AMP-activated protein kinase plays a role in the control of food intake." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12005-8, 2004 (PubMed).

Shaw, Kosmatka, Bardeesy et al.: "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3329-35, 2004 (PubMed).

Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

Alternatives for antigen "Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2)", type "Antibodies"
Hosts (124), (9), (3)
Reactivities (118), (83), (77), (29), (25), (13), (12), (12)
Applications (84), (50), (48), (22), (20), (12), (10), (6), (4), (2), (2), (1), (1), (1), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1)
Epitopes (25), (15), (12), (12), (12), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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