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Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (C-Term), (AA 476-507) antibody

Details for Product No. ABIN391306
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Antigen
Synonyms AMPK, AMPK2, AMPKa2, PRKAA, Ampk, Ampka2, A830082D05, AMPKalpha2, 2310008I11Rik, AMPKA2, ampk, ampk2, prkaa, prkaa1, PRKAA2
Epitope
C-Term, AA 476-507
(37), (16), (12), (12), (12), (8), (8), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(157), (82), (77), (27), (25), (13), (12), (12), (1)
Host
Rabbit
(156), (16), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB)
(120), (73), (50), (38), (24), (16), (12), (10), (3), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN391306
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-507 AA from the C-terminal region of human AMPK alpha2.
Clone RB2523
Isotype Ig
Specificity This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484~514 amino acids from the C-terminal region of human AMPK.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AMPK Alpha2
Background AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Synonyms: 5'-AMP-activated protein kinase, catalytic alpha-2 chain, AMPK alpha-2 chain
Molecular Weight 62319 DA
Gene ID 5563
UniProt P54646
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (C-Term), (AA 476-507) antibody Western blot analysis of anti-AMPK alpha2 C-term Pab (ABIN391306) in mouse heart tissue lysate. AMPK alpha2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Background publications Browne, Finn, Proud: "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12220-31, 2004 (PubMed).

Andersson, Filipsson, Abbott et al.: "AMP-activated protein kinase plays a role in the control of food intake." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12005-8, 2004 (PubMed).

Shaw, Kosmatka, Bardeesy et al.: "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3329-35, 2004 (PubMed).

Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391306
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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