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MAP3K12 antibody (C-Term)

MAP3K12 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB0976 unconjugated
Catalog No. ABIN391319
  • Target See all MAP3K12 Antibodies
    MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
    Binding Specificity
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 828-859, C-Term
    Reactivity
    • 35
    • 19
    • 12
    Human, Mouse
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 34
    • 2
    Polyclonal
    Conjugate
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K12 antibody is un-conjugated
    Application
    • 23
    • 23
    • 16
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This ZPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-859 amino acids from the C-terminal region of human ZPK.
    Clone
    RB0976
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:2000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Ye, Li, Yang, Xie, Yu, Ma, Zhu, Zhao, Lv: "MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 36, Issue 2, pp. 712-26, (2015) (PubMed).

    Couture, Blouin: "The DLK gene is a transcriptional target of PPAR?." in: The Biochemical journal, Vol. 438, Issue 1, pp. 93-101, (2011) (PubMed).

  • Target
    MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
    Alternative Name
    ZPK (MAP3K12 Products)
    Synonyms
    DLK antibody, MEKK12 antibody, MUK antibody, ZPK antibody, ZPKP1 antibody, PK antibody, Zpk antibody, zgc:77370 antibody, MGC151798 antibody, dlk antibody, map3k12 antibody, map3k12a antibody, mekk12 antibody, muk antibody, zpk antibody, zpkp1 antibody, DKFZp459K2433 antibody, map3k12-a antibody, map3k12-b antibody, map3k12b antibody, mitogen-activated protein kinase kinase kinase 12 antibody, mitogen activated protein kinase kinase kinase 12 antibody, mitogen-activated protein kinase kinase kinase 12 S homeolog antibody, mitogen-activated protein kinase kinase kinase 12 L homeolog antibody, MAP3K12 antibody, Map3k12 antibody, map3k12 antibody, map3k12.S antibody, map3k12.L antibody
    Background
    ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
    Molecular Weight
    93219
    Gene ID
    7786
    NCBI Accession
    NP_001180440, NP_006292
    UniProt
    Q12852
    Pathways
    MAPK Signaling
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