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MAPK14 antibody (Mitogen-Activated Protein Kinase 14) (AA 158-192)

Details for Product anti-MAPK14 Antibody No. ABIN391334, Supplier: Log in to see
Antigen
  • 186F5S
  • anon-sts23
  • AP22.98
  • AP22_98
  • ATMPK14
  • BG:DS00797.3
  • CG7393
  • CRK1
  • Crk1
  • CSBP
  • csbp
  • Csbp1
  • CSBP1
  • Csbp2
  • CSBP2
  • CSPB1
  • D-p38
  • D-p38 MAPK
  • D-p38b
  • Dmel\\CG7393
  • Dmp38b
  • Dm p38b
  • Dp38
  • dp38b
  • Dp38b
  • ESTS:186F5S
  • Exip
  • EXIP
  • Hog
  • mapk14a
  • mitogen-activated protein kinase 14
  • Mpk34C
  • Mxi2
  • mxi2
  • p38
  • p38 beta
  • p38 MAPK
  • p38-alpha
  • p38a
  • p38alpha
  • p38ALPHA
  • p38B
  • p38beta
  • p38Hog
  • p38Kb
  • p38MAPK
  • Prkm14
  • PRKM14
  • Prkm15
  • PRKM15
  • RK
  • sapk2
  • sapk2a
  • SAPK2A
  • Sapk2A
  • SAPK2a
Alternatives
anti-Human MAPK14 antibody for Western Blotting
Epitope
AA 158-192, Thr180, Tyr182
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25
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1
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Reactivity
Human, Mouse (Murine)
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80
73
18
8
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1
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Host
Rabbit
151
30
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1
Clonality (Clone)
Polyclonal ()
Conjugate
This MAPK14 antibody is un-conjugated
7
7
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5
5
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
163
77
53
28
23
10
9
8
7
7
5
2
1
Supplier
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Immunogen This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-192 AA from human MAPK14.
Clone RB15973
Isotype Ig
Specificity This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168~197 amino acids surrounding T180 of human MAPK14.
Predicted Reactivity Rat (Rattus),Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAPK14 (MAPK14 Antibody Abstract)
Background MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Synonyms: Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
Molecular Weight 41293 DA
Gene ID 1432
UniProt Q16539
Research Area Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways MAPK Signaling, TCR Signaling, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAPK14 antibody (Mitogen-Activated Protein Kinase 14) (AA 158-192) (ABIN391334) Western blot analysis of anti-MAPK14 Antibody (T180/Y182) (ABIN391334) in mouse lung ...
Immunohistochemistry (IHC) image for anti-MAPK14 antibody (Mitogen-Activated Protein Kinase 14) (AA 158-192) (ABIN391334) MAPK14 Antibody (T180/Y182)(ABIN391334) immunohistochemistry analysis in formalin fix...
Background publications Cheung, Campbell, Nebreda, Cohen: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003 (PubMed).

Dean, Sarsfield, Tsounakou, Saklatvala: "p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39470-6, 2003 (PubMed).