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beta 2 Adrenergic Receptor (BAR2) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN391396, Supplier: Log in to see
Antigen
Epitope
AA 1-30, N-Term
Reactivity
Human
Host
Rabbit
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
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Immunogen This beta 2 Adrenergic Receptor (BAR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human beta 2 Adrenergic Receptor (BAR2).
Clone RB10325
Isotype Ig
Specificity This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7~37 amino acids from the N-terminal region of human BAR2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Synonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR
Molecular Weight 46426 DA
Gene ID 154
NCBI Accession NP_000015
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-beta 2 Adrenergic Receptor (BAR2) (AA 1-30), (N-Term) antibody (ABIN391396) Western blot analysis of anti-BAR2 Antibody (N-term) (ABIN391396) in HL60 cell line l...
Product cited in: Simkins, Crawford, Goudreau, Lookingland, Kaplan: "Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 9, Issue 4, pp. 544-57, 2014 (PubMed).

Rodrigues, Tran, Fortes, Schmid-Schönbein: "Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats." in: American journal of physiology. Heart and circulatory physiology, Vol. 299, Issue 1, pp. H25-35, 2010 (PubMed).

Background publications Cherezov, Rosenbaum, Hanson, Rasmussen, Thian, Kobilka, Choi, Kuhn, Weis, Kobilka, Stevens: "High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 318, Issue 5854, pp. 1258-65, 2007 (PubMed).