beta 2 Adrenergic Receptor (BAR2) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN391396
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Antigen
Epitope
N-Term, AA 1-30
Reactivity
Human
Host
Rabbit
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN391396
Quantity 400 µL
Price
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Immunogen This beta 2 Adrenergic Receptor (BAR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human beta 2 Adrenergic Receptor (BAR2).
Clone RB10325
Isotype Ig
Specificity This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7~37 amino acids from the N-terminal region of human BAR2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Synonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR
Molecular Weight 46426 DA
Gene ID 154
UniProt NP_000015
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-beta 2 Adrenergic Receptor (BAR2) (N-Term), (AA 1-30) antibody Western blot analysis of anti-BAR2 Antibody (N-term) (ABIN391396) in HL60 cell line lysates (35 µg/lane). BAR2(arrow) was detected using the purified polyclonal antibody (1:440 dilution).
Product cited in: Simkins, Crawford, Goudreau et al.: "Enhanced Humoral Immunity in Mice Lacking CB1 and CB2 Receptors (Cnr1 (-/-) /Cnr2 (-/-) Mice) is not Due to Increased Splenic Noradrenergic Neuronal Activity." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2014 (PubMed).

Background publications Cherezov, Rosenbaum, Hanson et al.: "High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 318, Issue 5854, pp. 1258-65, 2007 (PubMed).

General Rodrigues, Tran, Fortes et al.: "Matrix Metalloproteinases Cleave the {beta}2 -Adrenergic Receptor in the Spontaneously Hypertensive Rats." in: American journal of physiology. Heart and circulatory physiology, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

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  • +1 888 205 9894 (TF)
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