Cyclin A antibody (Cyclin A2) (AA 358-389)

Details for Product anti-CCNA2 Antibody No. ABIN391455, Supplier: Log in to see
Antigen
  • ccn1
  • ccna
  • ccna1
  • CCN1
  • CCNA
  • AA408589
  • Ccn-1
  • Ccn1
  • Ccna
  • CycA2
  • Cyca
  • cb671
  • chunp6924
  • wu:fi36f03
  • CYCA
  • Cyclin-A2
  • ccna2
  • Cyclin-A
  • cyclinA
  • cyclin A2
  • cyclin A
  • ccna2
  • CCNA2
  • LOC100352785
  • Ccna2
  • LOC397933
Alternatives
anti-Human Cyclin A antibody for Chromatin Immunoprecipitation
Epitope
AA 358-389, C-Term
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18
6
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4
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3
2
1
1
1
1
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1
Reactivity
Human
192
102
68
35
21
21
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19
5
4
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3
2
2
1
1
1
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1
Host
Rabbit
160
67
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Cyclin A antibody is un-conjugated
8
7
7
7
7
7
7
7
7
7
7
7
7
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6
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
183
79
59
51
47
42
37
30
29
5
4
4
2
1
1
1
Options
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Immunogen This CCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 AA from the C-terminal region of human CCNA2.
Clone RB14702
Isotype Ig
Specificity This CCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367~396 amino acids from the C-terminal region of human CCNA2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CCNA2 (CCNA2 Antibody Abstract)
Background CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Synonyms: Cyclin-A2, Cyclin-A, CCNA2, CCN1, CCNA
Molecular Weight 48537 DA
Gene ID 890
UniProt P20248
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle
Pathways PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cyclin A antibody (Cyclin A2) (AA 358-389) (ABIN391455) Western blot analysis of CCNA2 (arrow) using rabbit polyclonal CCNA2 Antibody (C-term...
Immunohistochemistry (IHC) image for anti-Cyclin A antibody (Cyclin A2) (AA 358-389) (ABIN391455) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CCNA2...
Background publications Tsang, Wang, Chen, Sánchez, Dynlacht: "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression." in: The Journal of cell biology, Vol. 178, Issue 4, pp. 621-33, 2007 (PubMed).

Henglein, Chenivesse, Wang, Eick, Bréchot: "Structure and cell cycle-regulated transcription of the human cyclin A gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5490-4, 1994 (PubMed).

Wang, Chenivesse, Henglein, Bréchot: "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma." in: Nature, Vol. 343, Issue 6258, pp. 555-7, 1990 (PubMed).