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Details for Product No. ABIN391605

Vaccinia Related Kinase 1 (VRK1) (AA 366-396), (Center) antibody

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Antigen
Synonyms PCH1, PCH1A, 51PK, vrk1, MGC64390, MGC75762, zgc:56266, wu:fe16f06, VRK1
Epitope
»Alternatives AA 366-396, Center
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN391605
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This VRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-396 AA from the Central region of human VRK1.
Clone RB2997
Isotype Ig
Specificity This VRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367~396 amino acids from the center region of human VRK1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VRK1
Background This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Synonyms: vaccinia related kinase 1, Serine/threonine-protein kinase VRK1
Molecular Weight 45476 DA
Gene ID 7443
UniProt Q99986
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Nezu, Oku, Jones et al.: "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase." in: Genomics, Vol. 45, Issue 2, pp. 327-31, 1998 (PubMed).

Alternatives for antigen "Vaccinia Related Kinase 1 (VRK1)", type "Antibodies"
Hosts (18), (7)
Reactivities (25), (14), (11), (11), (11)
Applications (16), (9), (7), (4), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (1), (1), (1), (1)
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