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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) (C-Term), (AA 1117-1145) antibody

Details for Product No. ABIN391639
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Antigen
Epitope
C-Term, AA 1117-1145
(11), (9), (5), (4), (4), (3), (1), (1), (1)
Reactivity
Human
(63), (23), (21), (12), (12), (12), (12), (1)
Host
Rabbit
(28), (19), (11), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (29), (18), (16), (11), (10), (10), (8), (7), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391639
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Immunogen This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1117-1145 AA from the C-terminal region of human ABCC4.
Clone RB17763
Isotype Ig
Specificity This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1124~1153 amino acids from the C-terminal region of human ABCC4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ABCC4
Background ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Synonyms: Multi-specific organic anion transporter B, MOAT-B, MRP/cMOAT-related ABC transporter, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, ABCC4, MRP4
Molecular Weight 149527 DA
Gene ID 10257
UniProt O15439
Research Area Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) (C-Term), (AA 1117-1145) antibody Western blot analysis of anti-ABCC4 Antibody (C-term) (ABIN391639) in CEM cell line lysates (35 µg/lane). ABCC4 (arrow) was detected using the purified polyclonal antibody.
Background publications Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

Lee, Belinsky, Bell et al.: "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." in: Cancer research, Vol. 58, Issue 13, pp. 2741-7, 1998 (PubMed).

Adachi, Sampath, Lan et al.: "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38998-9004, 2002 (PubMed).

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