|+1 404 474 4654|
|+1 888 205 9894 (TF)|
ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (Center) antibody
|Synonyms||Gm710, vWF-CP, ADAMTS13, TTP, VWFCP, C9orf8, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, PRO4389, MGC126403, FLJ16363, FLJ32769, AI605170, ADAMTS-12, ADAMTS12|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836~866 amino acids from the center region of human ADAMTS13.|
|Description||Other names: von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAMTS-13, ADAM-TS 13, ADAM-TS13, ADAMTS13, C9orf8|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836~866 amino acids from the center region of human ADAMTS13.|
|Molecular Weight||153604 DA|
Background: ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Metabolism, Cell Structure|
|Restrictions||For Research Use only|
Zheng, Chung, Takayama et al.: "Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 41059-63, 2001 (PubMed).
Levy, Nichols, Lian et al.: "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura." in: Nature, Vol. 413, Issue 6855, pp. 488-94, 2001 (PubMed).
Plaimauer, Fuhrmann, Mohr et al.: "Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation." in: Blood, Vol. 107, Issue 1, pp. 118-25, 2005 (PubMed).
|Hosts||Rabbit (23), Mouse (8), Sheep (2)|
|Reactivities||Human (33), Mouse (Murine) (18)|
|Applications||Immunofluorescence (IF) (18), Western Blotting (WB) (17), ELISA (13), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunohistochemistry (IHC) (1)|
|Conjugates||Biotin (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 34-688 (3), AA 686-894 (2), C-Term (2), AA 250-350 (1), Internal Region (1), N-Term (1)|