Fatty Acid Synthase (FASN) (AA 942-973), (Center) antibody

Details for Product No. ABIN391654
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Antigen
Synonyms
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, ... show more
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, A630082H08Rik show less
Epitope
AA 942-973, Center
(8), (8), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(65), (20), (13), (4), (2), (1), (1)
Host
Rabbit
(48), (19), (4)
Clonality (Clone)
Polyclonal ()
Application
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(65), (25), (22), (21), (12), (12), (12), (5), (5), (3)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN391654
291.50 $
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Immunogen This FASN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 942-973 AA from the Central region of human FASN.
Clone RB17743
Isotype Ig
Specificity This FASN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 950~980 amino acids from the Center region of human FASN.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FASN
Background FASN is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Synonyms: FAS, Fatty acid synthase
Pathways: Insulin signaling pathway
Molecular Weight 273400 Da
Gene ID 2194
UniProt P49327
Research Area Metabolism, Cell Structure
Application Notes IF = 1:10-50, WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fatty Acid Synthase (FASN) (AA 942-973), (Center) antibody Western blot analysis of FASN Antibody (Center) (ABIN391654) in Ramos cell line lysates (35 µg/lane).FASN (arrow) was detected using the purified polyclonal antibody.
anti-Fatty Acid Synthase (FASN) (AA 942-973), (Center) antibody (2) Western blot analysis of FASN (arrow) using rabbit polyclonal FASN Antibody (Center)(ABIN391654). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the FASN gene (Lane 2) (Origene Technologies).
Background publications Jayakumar, Tai, Huang et al.: "Human fatty acid synthase: properties and molecular cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8695-9, 1995 (PubMed).

Kuhajda, Jenner, Wood et al.: "Fatty acid synthesis: a potential selective target for antineoplastic therapy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 14, pp. 6379-83, 1994 (PubMed).

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