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JNK antibody (Mitogen-Activated Protein Kinase 8) (AA 358-389)

Details for Product anti-MAPK8 Antibody No. ABIN391724, Supplier: Log in to see
Antigen
  • AI849689
  • Bsk
  • BSK
  • BSK/DJNK
  • c-Jun
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • dJNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • jnk
  • JNK
  • Jnk
  • JNK-46
  • JNK/SAPK
  • JNK1
  • jnk1
  • JNK1A2
  • JNK21B1/2
  • Junk
  • mapk8
  • Prkm8
  • PRKM8
  • sapk1
  • SAPK1
  • SAPK1c
  • SAPKa
  • T10F20.15
  • zgc:112379
Alternatives
anti-Human JNK antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 358-389, C-Term
96
58
32
22
18
15
15
15
13
13
13
10
10
10
10
5
5
5
5
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2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
373
132
112
17
15
7
6
4
2
2
2
1
1
Host
Rabbit
305
94
2
Clonality (Clone)
Polyclonal ()
Conjugate
This JNK antibody is un-conjugated
18
16
14
11
11
10
4
3
3
3
3
3
3
3
3
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
298
195
92
64
52
51
39
33
17
14
10
6
4
3
2
2
1
1
1
1
1
1
Supplier
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Immunogen This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 AA from the C-terminal region of human MAPK8.
Clone RB0922
Isotype Ig
Specificity This JNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366~396 amino acids from the C-terminal region of human JNK1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JNK1 (MAPK8 Antibody Abstract)
Background JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.
Synonyms: Mitogen-activated protein kinase 8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, JNK-46
Molecular Weight 48295 DA
Gene ID 5599
UniProt P45983
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways MAPK Signaling, WNT Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IF = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-JNK antibody (Mitogen-Activated Protein Kinase 8) (AA 358-389) (ABIN391724) Western blot analysis of anti-JNK1 Pab (ABIN391724) in HL60 (UV-treated) cell lysate....
Product cited in: Li, Sahbaie, Zheng, Ritchie, Peltz, Mogil, Clark: "Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors." in: Molecular pain, Vol. 6, pp. 11, 2010 (PubMed).

Background publications Deng, Ren, Yang, Lin, Wu: "A JNK-dependent pathway is required for TNFalpha-induced apoptosis." in: Cell, Vol. 115, Issue 1, pp. 61-70, 2003 (PubMed).

Luo, Ng, Jin, Ye, Han, Lin: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, 2003 (PubMed).

Ghosh: "Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase." in: Biochemical and biophysical research communications, Vol. 307, Issue 2, pp. 342-9, 2003 (PubMed).

Utsugi, Dobashi, Ishizuka, Endou, Hamuro, Murata, Nakazawa, Mori: "c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 628-35, 2003 (PubMed).

Vivo, Liu, Broaddus: "c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25461-7, 2003 (PubMed).