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MAPK10 antibody (Mitogen-Activated Protein Kinase 10) (AA 1-30)

Details for Product anti-MAPK10 Antibody No. ABIN391727, Supplier: Log in to see
Antigen
  • MAPK10
  • zgc:123234
  • DKFZp459H0638
  • Jnk3
  • SAPKC
  • SAPb
  • Serk2
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1b
  • p493F12
  • p54bSAPK
  • C230008H04Rik
  • JNK3B1
  • JNK3B2
  • SAPK(beta)
  • ATMPK10
  • MAP kinase 10
Alternatives
anti-Human MAPK10 antibody for Western Blotting
Epitope
AA 1-30, N-Term
48
17
8
6
5
4
3
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
112
49
34
Host
Rabbit
100
21
Clonality (Clone)
Polyclonal ()
Conjugate
This MAPK10 antibody is un-conjugated
8
7
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
100
75
51
16
11
9
9
3
2
2
1
Supplier
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Immunogen This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human MAPK10.
Clone RB01017
Isotype Ig
Specificity This JNK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human JNK3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JNK3 (MAPK10 Antibody Abstract)
Background JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Synonyms: c-Jun N-terminal kinase 3, Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3, MAP kinase p49 3F12
Molecular Weight 52585 DA
Gene ID 5602
UniProt P53779
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Pathways MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAPK10 antibody (Mitogen-Activated Protein Kinase 10) (AA 1-30) (ABIN391727) Western blot analysis of anti-JNK3 Antibody (N-term) (ABIN391727) in mouse brain tiss...
Immunohistochemistry (IHC) image for anti-MAPK10 antibody (Mitogen-Activated Protein Kinase 10) (AA 1-30) (ABIN391727) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Kuo, Hu, Hsu et al.: "Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin." in: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4201-12, 2008 (PubMed).

Background publications Yoshida, Harada, Nagai et al.: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, 2002 (PubMed).

McDonald, Chow, Miller et al.: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, 2000 (PubMed).

Yang, Kuan, Whitmarsh et al.: "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene." in: Nature, Vol. 389, Issue 6653, pp. 865-70, 1997 (PubMed).

Gupta, Barrett, Whitmarsh et al.: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, 1996 (PubMed).