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CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 230-260)

Details for Product anti-CDK1 Antibody No. ABIN391742, Supplier: Log in to see
Antigen
  • 5363
  • CDC2
  • CDCDm
  • CDK1
  • CDK1/CDC2
  • CG5363
  • Cdc2
  • Cdk-1
  • Cdk1
  • Dcdc2
  • Dm cdc2
  • DmCdc2
  • DmCdk1
  • Dmcdc2
  • Dmel\\CG5363
  • cdc
  • cdc2Dm
  • cdk1
  • dCdk1
  • group 4
  • l(2)31Eh
  • CDC28A
  • P34CDC2
  • Cdc2a
  • p34
  • cdc2
  • wu:fc30e01
  • zgc:92032
  • PSTAIR
  • cdc-2
  • cdc2-a
  • cdc28a
  • cdc2x1.1
  • p34cdc2
  • xcdc2
  • CDC2A
  • CDC2AAT
  • CDK2
  • CDKA1
  • CDKA;1
  • CYCLIN-DEPENDENT KINASE A;1
  • cell division control 2
  • POL3
  • pold
Alternatives
anti-Human CDK1 antibody for Immunocytochemistry
Epitope
AA 230-260, C-Term
88
69
47
32
28
27
19
18
15
14
14
14
14
14
8
8
6
5
5
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
589
255
224
25
23
21
16
10
6
5
5
5
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Host
Rabbit
484
141
Clonality (Clone)
Polyclonal ()
Conjugate
This CDK1 antibody is un-conjugated
25
21
18
14
13
13
6
5
5
5
5
5
5
5
5
1
1
Application
Western Blotting (WB)
498
224
157
99
89
69
57
33
31
14
11
10
7
6
6
2
1
1
Supplier
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Immunogen This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 AA from the C-terminal region of human CDC2 (CDK1).
Clone RB3126
Isotype Ig
Specificity This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238~267 amino acids from the C-terminal region of human CDK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDC2 (CDK1) (CDK1 Antibody Abstract)
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: Cell division control protein 2 homolog, p34 protein kinase, Cyclin-dependent kinase 1
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 230-260) (ABIN391742) Western blot analysis of anti-CDK1 Pab (ABIN391742) in A375 cell lysate. CDK1 (arrow)...
Background publications Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

Nozoe, Honda, Inutsuka et al.: "p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma." in: Journal of cancer research and clinical oncology, Vol. 129, Issue 9, pp. 498-502, 2003 (PubMed).

Margottin-Goguet, Hsu, Loktev et al.: "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase." in: Developmental cell, Vol. 4, Issue 6, pp. 813-26, 2003 (PubMed).

Manes, Zheng, Tognin et al.: "Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration." in: The Journal of cell biology, Vol. 161, Issue 4, pp. 817-26, 2003 (PubMed).

Yuan, Xie, Chen: "Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis." in: Journal of virology, Vol. 77, Issue 3, pp. 2063-70, 2003 (PubMed).