Cyclin-Dependent Kinase 1 (CDK1) (C-Term), (AA 230-260) antibody

Details for Product No. ABIN391742
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Antigen
Synonyms
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc ... show more
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, PSTAIR, cdc-2, cdc2-a, cdc28a, cdc2x1.1, p34cdc2, xcdc2, CDC2A, CDC2AAT, CDK2, CDKA1, CDKA;1, CYCLIN-DEPENDENT KINASE A;1, cell division control 2, POL3, pold show less
Epitope
C-Term, AA 230-260
(62), (52), (52), (28), (18), (18), (17), (13), (12), (9), (7), (7), (6), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(477), (246), (233), (43), (36), (30), (26), (26), (16), (6), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(395), (124)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(21), (15), (15), (9), (9), (9), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application
Western Blotting (WB)
(431), (198), (115), (111), (65), (63), (60), (46), (21), (17), (10), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN391742
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Immunogen This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 AA from the C-terminal region of human CDC2 (CDK1).
Clone RB3126
Isotype Ig
Specificity This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238~267 amino acids from the C-terminal region of human CDK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDC2 (CDK1)
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: Cell division control protein 2 homolog, p34 protein kinase, Cyclin-dependent kinase 1
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase 1 (CDK1) (C-Term), (AA 230-260) antibody Western blot analysis of anti-CDK1 Pab (ABIN391742) in A375 cell lysate. CDK1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Background publications Yuan, Xie, Chen: "Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis." in: Journal of virology, Vol. 77, Issue 3, pp. 2063-70, 2003 (PubMed).

Manes, Zheng, Tognin et al.: "Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration." in: The Journal of cell biology, Vol. 161, Issue 4, pp. 817-26, 2003 (PubMed).

Margottin-Goguet, Hsu, Loktev et al.: "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase." in: Developmental cell, Vol. 4, Issue 6, pp. 813-26, 2003 (PubMed).

Nozoe, Honda, Inutsuka et al.: "p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma." in: Journal of cancer research and clinical oncology, Vol. 129, Issue 9, pp. 498-502, 2003 (PubMed).

Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

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