|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cyclin-Dependent Kinase 9 (CDK9) (C-Term) antibody
|Synonyms||TAK, C-2k, CTK1, CDC2L4, PITALRE, CDK9, P-TEF, P-TEFb, PTefb, DmelCG5179, CG5179, wu:fb22e09, wu:fc06c02, MGC95175, cdk9, MGC53831, MGC139578, tak, c-2k, cdc2l4, pitalre, MGC69296|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This CDK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343~372 amino acids from the C-terminal region of human CDK9.|
|Description||Other names: Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, C-2K|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CDK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343~372 amino acids from the C-terminal region of human CDK9.|
|Molecular Weight||42791 DA|
Background: CKD9 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Graña, De Luca, Sang et al.: "PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 9, pp. 3834-8, 1994 (PubMed).
Fu, Peng, Lee et al.: "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 34527-30, 2000 (PubMed).
Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).