DYRK1B antibody (C-Term)

Catalog No. ABIN391774

Product Details anti-DYRK1B Antibody

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Binding Specificity: AA 561-589, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the C-terminal region of human DYRK1B.

Clone: RB3017

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-DYRK1B antibody (ABIN391774)

Gao, Zhao, Lv, Chen, Wei, Tian, Yang, Kong, Pang, Liu, Shi: "Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells." in: Cancer cell international, Vol. 13, Issue 1, pp. 2, (2013) (PubMed).

Gao, Yang, Yin, Hu, Liao, Miao, Pan, Li: "The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer." in: International journal of oncology, Vol. 40, Issue 4, pp. 1203-9, (2012) (PubMed).

Lee, Ha, Kim, Kim, Chang, Song, Kim: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).

Takahashi-Yanaga, Mori, Matsuzaki, Watanabe, Hirata, Miwa, Morimoto, Sasaguri: "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells." in: The Journal of biological chemistry, Vol. 281, Issue 50, pp. 38489-97, (2006) (PubMed).

Target Details for DYRK1B

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Alternative Name: DYRK1B (DYRK1B Products)

Synonyms: DYRK1B antibody, MIRK antibody, Mirk antibody, DYRK1A antibody, dual specificity tyrosine phosphorylation regulated kinase 1B antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b antibody, DYRK1B antibody, Dyrk1b antibody

Background: DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.

Molecular Weight: 69198

Gene ID: 9149

NCBI Accession: NP_004705, NP_006474, NP_006475

UniProt: Q9Y463