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ACAT1 antibody (Acetyl-CoA Acetyltransferase 1) (AA 296-329)

Details for Product anti-ACAT1 Antibody No. ABIN391807, Supplier: Log in to see
Antigen
  • 6330585C21Rik
  • Acat
  • ACAT
  • acat1-a
  • fd16h07
  • fd20g06
  • MAT
  • RATACAL
  • T2
  • THIL
  • wu:fd16h07
  • wu:fd20g06
  • zgc:86832
Epitope
AA 296-329, C-Term
22
21
10
8
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
142
50
47
5
4
3
2
2
2
1
1
1
1
1
Host
Rabbit
86
36
27
Clonality (Clone)
Polyclonal ()
Conjugate
This ACAT1 antibody is un-conjugated
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
128
87
36
31
16
11
7
7
3
1
Supplier
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Immunogen This ACAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-329 AA from the C-terminal region of human ACAT1.
Clone RB14644
Isotype Ig
Specificity This ACAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305~335 amino acids from the C-terminal region of human ACAT1.
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACAT1 (ACAT1 Antibody Abstract)
Background ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Synonyms: Acetyl-CoA acetyltransferase, mitochondrial [Precursor], Acetoacetyl-CoA thiolase, T2,
Molecular Weight 45200 DA
Gene ID 38
UniProt P24752
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ACAT1 antibody (Acetyl-CoA Acetyltransferase 1) (AA 296-329) (ABIN391807) Western blot analysis of anti-ACAT1 Pab (ABIN391807) in SK-BR-3 cell line lysates (35...
Immunohistochemistry (IHC) image for anti-ACAT1 antibody (Acetyl-CoA Acetyltransferase 1) (AA 296-329) (ABIN391807) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ACAT1 ...
Background publications Guo, Chang, Chang: "Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1." in: Biochemistry, Vol. 46, Issue 35, pp. 10063-71, 2007 (PubMed).

Haapalainen, Meriläinen, Pirilä, Kondo, Fukao, Wierenga: "Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function." in: Biochemistry, Vol. 46, Issue 14, pp. 4305-21, 2007 (PubMed).