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EPH Receptor B6 antibody (C-Term)

EPHB6 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB1666 unconjugated
Catalog No. ABIN391928
  • Target See all EPH Receptor B6 (EPHB6) Antibodies
    EPH Receptor B6 (EPHB6)
    Binding Specificity
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 990-1021, C-Term
    Reactivity
    • 78
    • 32
    • 22
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 74
    • 4
    • 1
    • 1
    Rabbit
    Clonality
    • 75
    • 5
    Polyclonal
    Conjugate
    • 32
    • 9
    • 8
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This EPH Receptor B6 antibody is un-conjugated
    Application
    • 59
    • 51
    • 38
    • 13
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 990-1021 amino acids from the C-terminal region of human EphB6.
    Clone
    RB1666
    Isotype
    Ig Fraction
    Top Product
    Discover our top product EPHB6 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Gu, Li, Qian, Chen, Wang, Wang: "Expression of EphB6 in ovarian serous carcinoma is associated with grade, TNM stage and survival." in: Journal of clinical pathology, (2015) (PubMed).

    Brantley-Sieders, Jiang, Sarma, Badu-Nkansah, Walter, Shyr, Chen: "Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome." in: PLoS ONE, Vol. 6, Issue 9, pp. e24426, (2011) (PubMed).

    Yu, Bulk, Ji, Hascher, Tang, Metzger, Marra, Serve, Berdel, Wiewroth, Koschmieder, Müller-Tidow: "The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2275-83, (2010) (PubMed).

  • Target
    EPH Receptor B6 (EPHB6)
    Alternative Name
    EphB6 (EPHB6 Products)
    Synonyms
    CEK9 antibody, EPHB5 antibody, Cekl antibody, Mep antibody, HEP antibody, EPH receptor B6 antibody, Eph receptor B6 antibody, EPHB6 antibody, Ephb6 antibody
    Background
    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
    Molecular Weight
    110700
    Gene ID
    2051
    NCBI Accession
    NP_001267723, NP_001267724, NP_004436
    UniProt
    O15197
    Pathways
    RTK Signaling, Hormone Transport
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