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Details for Product No. ABIN391950

V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (N-Term), (AA 25-55) antibody

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Antigen
Synonyms HER4, p180erbB4, Her4, c-erbB-4, erbb4, si:ch211-227n20.1
Epitope
»Alternatives N-Term, AA 25-55
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN391950
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ERBB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 AA from the N-terminal region of human ERBB4.
Clone RB01469
Isotype Ig
Specificity This ErbB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human ErbB4.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ErbB4
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Synonyms: Tyrosine kinase-type cell surface receptor HER4 , HER4
Molecular Weight 146807 DA
Gene ID 2066
UniProt Q15303
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.71 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Ni, Yuan, Carpenter: "Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4561-5, 2003 (PubMed).

Komuro, Nagai, Navin et al.: "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33334-41, 2003 (PubMed).

Cheng, Tikhomirov, Zhou et al.: "Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38421-7, 2003 (PubMed).

Alternatives for antigen "V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4)", type "Antibodies"
Hosts (192), (33)
Reactivities (220), (126), (124), (37), (37), (25), (25), (12), (2), (1), (1), (1), (1)
Applications (81), (80), (66), (48), (29), (25), (23), (18), (9), (2), (2), (2), (1)
Conjugates (14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (1), (1)
Epitopes (20), (20), (20), (19), (14), (13), (12), (10), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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