FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (AA 7-37)

Details for Product anti-FGFR2 Antibody No. ABIN391965, Supplier: Log in to see
Antigen
  • FGFR2
  • FGFR2IIIb
  • bek
  • bfr-1
  • cd332
  • cek3
  • cfd1
  • ect1
  • fgfr-2
  • jws
  • k-sam
  • kgfr
  • tk14
  • tk25
  • xfgfr2
  • DKFZp469H1521
  • BBDS
  • BEK
  • BFR-1
  • CD332
  • CEK3
  • CFD1
  • ECT1
  • JWS
  • K-SAM
  • KGFR
  • TK14
  • TK25
  • AU043015
  • AW556123
  • Bek
  • Fgfr-2
  • Fgfr-7
  • Fgfr7
  • KGFRTr
  • svs
  • FGF-R
  • fgfr72IIIb
  • FGFR
  • fc56c05
  • wu:fc56c05
  • fibroblast growth factor receptor 2
  • FGFR2
  • fgfr2
  • Fgfr2
Alternatives
anti-Rat (Rattus) FGFR2 antibody for ELISA
Epitope
AA 7-37, N-Term
25
24
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20
14
9
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2
1
1
1
1
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1
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Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
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63
12
6
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4
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3
3
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1
Host
Rabbit
208
87
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Clonality (Clone)
Polyclonal ()
Conjugate
This FGFR2 antibody is un-conjugated
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2
1
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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68
16
13
11
8
4
4
1
1
1
1
Options
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-37 AA from the N-terminal region of human FGFR2.
Clone RB01567
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~44 amino acids from the N-terminal region of human FGFR2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FGFR2 (FGFR2 Antibody Abstract)
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.
Synonyms: fibroblast growth factor receptor 2
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
Application Notes WB = 1:1000, IF = 1:50-100, FACS = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (AA 7-37) (ABIN391965) Western blot analysis of anti-hFGFR2-R22 Pab (ABIN391965) in 293 cell line lysates tr...
Immunohistochemistry (IHC) image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (AA 7-37) (ABIN391965) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
 image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (AA 7-37) (ABIN391965) C:FGFR2/isolectinB4 (C) and FGFR1/isolectinB4 (D) staining of apparent mesenchymal ce...
Product cited in: Guan, Gao, Zhou, Wang, Zheng, Guo, Chang, Li, Wang: "miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 5, pp. 1589-600, 2015 (PubMed).

Matsui-Inohara, Uematsu, Narita, Satoh, Yonezawa, Kuroda, Ito, Yoneda, Kawarai, Sugiya, Watanabe, Senpuku: "E2F-1-deficient NOD/SCID mice developed showing decreased saliva production." in: Experimental biology and medicine (Maywood, N.J.), Vol. 234, Issue 12, pp. 1525-36, 2009 (PubMed).

Page, Ambady, Holmes, Vilner, Kole, Kashpur, Huntress, Vojtic, Whitton, Dominko: "Induction of stem cell gene expression in adult human fibroblasts without transgenes." in: Cloning and stem cells, Vol. 11, Issue 3, pp. 417-26, 2009 (PubMed).

Mondrinos, Koutzaki, Lelkes, Finck: "A tissue-engineered model of fetal distal lung tissue." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 293, Issue 3, pp. L639-50, 2007 (PubMed).

Background publications Freeman, Gangula, Welm, Ozen, Foster, Rosen, Ittmann, Greenberg, Spencer et al.: "Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase ..." in: Cancer research, Vol. 63, Issue 19, pp. 6237-43, 2003 (PubMed).

Goriely, McVean, Röjmyr, Ingemarsson, Wilkie: "Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line." in: Science (New York, N.Y.), Vol. 301, Issue 5633, pp. 643-6, 2003 (PubMed).

Fomenkov, Huang, Topaloglu, Brechman, Osada, Fomenkova, Yuriditsky, Trink, Sidransky, Ratovitski: "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23906-14, 2003 (PubMed).

Katoh, Katoh: "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26." in: International journal of molecular medicine, Vol. 11, Issue 5, pp. 579-83, 2003 (PubMed).

Katoh, Katoh: "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26." in: International journal of oncology, Vol. 22, Issue 5, pp. 1155-9, 2003 (PubMed).