FGFR2 antibody (Fibroblast Growth Factor Receptor 2)

Details for Product anti-FGFR2 Antibody No. ABIN391968, Supplier: Log in to see
Antigen
  • FGFR2
  • FGFR2IIIb
  • bek
  • bfr-1
  • cd332
  • cek3
  • cfd1
  • ect1
  • fgfr-2
  • jws
  • k-sam
  • kgfr
  • tk14
  • tk25
  • xfgfr2
  • DKFZp469H1521
  • BBDS
  • BEK
  • BFR-1
  • CD332
  • CEK3
  • CFD1
  • ECT1
  • JWS
  • K-SAM
  • KGFR
  • TK14
  • TK25
  • AU043015
  • AW556123
  • Bek
  • Fgfr-2
  • Fgfr-7
  • Fgfr7
  • KGFRTr
  • svs
  • FGF-R
  • fgfr72IIIb
  • FGFR
  • fc56c05
  • wu:fc56c05
  • fibroblast growth factor receptor 2
  • FGFR2
  • fgfr2
  • Fgfr2
Alternatives
anti-Human FGFR2 antibody for Cell Culture
Reactivity
Human
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Host
Rabbit
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Clonality (Clone)
Polyclonal ()
Conjugate
This FGFR2 antibody is un-conjugated
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Clone RB17696
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR2 (FGFR2 Antibody Abstract)
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
Synonyms: Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, CD332, BEK, KGFR, KSAM
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Protein Modifications, Cell Structure, Cell Cycle
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (ABIN391968) Western blot analysis of FGFR2 Antibody (ABIN391968) in NCI-H460 cell line lysates (3...
Western Blotting (WB) image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (ABIN391968) Western blot analysis of FGFR2 (arrow) using rabbit polyclonal FGFR2 Antibody (ABIN39...
Immunohistochemistry (IHC) image for anti-FGFR2 antibody (Fibroblast Growth Factor Receptor 2) (ABIN391968) Formalin-fixed and paraffin-embedded human lung carcinoma with FGFR2 Antibody, which ...
Background publications McGillivray, Savarirayan, Cox, Stojkoski, McNeil, Bankier, Bateman, Roscioli, Gardner, Lamandé: "Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain." in: Journal of medical genetics, Vol. 42, Issue 8, pp. 656-62, 2005 (PubMed).

Park, Meyers, Li, Theda, Day, Orlow, Jones, Jabs: "Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability." in: Human molecular genetics, Vol. 4, Issue 7, pp. 1229-33, 1996 (PubMed).

Rutland, Pulleyn, Reardon, Baraitser, Hayward, Jones, Malcolm, Winter, Oldridge, Slaney: "Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes." in: Nature genetics, Vol. 9, Issue 2, pp. 173-6, 1995 (PubMed).