FGFR3 antibody (Fibroblast Growth Factor Receptor 3) (AA 776-806)

Details for Product anti-FGFR3 Antibody No. ABIN391969, Supplier: Log in to see
Antigen
  • FGFR3
  • LOC100034114
  • ACH
  • CD333
  • CEK2
  • HSFGFR3EX
  • JTK4
  • FR3
  • Fgfr-3
  • Flg-2
  • HBGFR
  • Mfr3
  • sam3
  • fc27h01
  • wu:fc27h01
  • fibroblast growth factor receptor 3
  • FGF receptor 3
  • FGFR3
  • LOC100034114
  • fgfr3
  • Fgfr3
Alternatives
anti-Human FGFR3 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 776-806, C-Term
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Reactivity
Human
201
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Host
Rabbit
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Clonality (Clone)
Polyclonal ()
Conjugate
This FGFR3 antibody is un-conjugated
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-806 AA from the C-terminal region of human FGFR3.
Clone RB01572
Isotype Ig
Specificity This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 777~806 amino acids from the C-terminal region of human FGFR3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR3 (FGFR3 Antibody Abstract)
Background FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Synonyms: fibroblast growth factor receptor 3
Molecular Weight 87709 DA
Gene ID 2261
UniProt P22607
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 776-806), (C-Term) antibody (ABIN391969) Western blot analysis of anti-FGFR3 Pab (ABIN391969) in Jurkat cell lysate. FGFR3 (Ar...
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 776-806), (C-Term) antibody (ABIN391969) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Sturla, Merrick, Burchill: "FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells." in: British journal of cancer, Vol. 89, Issue 7, pp. 1276-84, 2003 (PubMed).

Lievens, Liboi et al.: "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) ..." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17344-9, 2003 (PubMed).

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