Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (N-Term), (AA 17-47) antibody

Details for Product No. ABIN392014
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Antigen
Synonyms
CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, Cak, Nep, CD167a, AI323681, 6030432F18, DDR1, CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, Dmel\\CG33531, Dmel ... show more
CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, Cak, Nep, CD167a, AI323681, 6030432F18, DDR1, CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, Dmel\\CG33531, Dmel_CG13984 show less
Epitope
N-Term, AA 17-47
(19), (15), (11), (5), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(86), (39), (38), (13), (12), (1)
Host
Rabbit
(75), (11), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(58), (40), (22), (20), (14), (5), (3), (1), (1)
Pubmed 3 references available
Catalog no. ABIN392014
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 AA from the N-terminal region of human DDR1.
Clone RB01477
Isotype Ig
Specificity This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24~54 amino acids from the N-terminal region of human MCK10.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DDR1
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.
Synonyms: discoidin receptor tyrosine kinase isoform a, PTK3A protein tyrosine kinase 3A, cell adhesion kinase, epithelial discoidin domain receptor 1, neurotrophic tyrosine kinase, receptor, type 4, neuroepithelial tyrosine kinase, mammarian carcinoma kinase 10
Molecular Weight 101127 Da
Gene ID 780
UniProt Q08345
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.26 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (N-Term), (AA 17-47) antibody Western blot analysis of anti-MCK10 Pab (ABIN392014) in placenta lysate. MCK10 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (N-Term), (AA 17-47) antibody (2) DDR1 Antibody (N-term) (ABIN392014)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995 (PubMed).

Valent, Meddeb, Danglot et al.: "Assignment of the NTRK4 (trkE) gene to chromosome 6p21." in: Human genetics, Vol. 98, Issue 1, pp. 12-5, 1996 (PubMed).

Vogel, Gish, Alves et al.: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998 (PubMed).

Hosts (75), (11), (1)
Reactivities (86), (39), (38), (13), (12), (1)
Applications (58), (40), (22), (20), (14), (5), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (19), (15), (11), (5), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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