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C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (N-Term), (AA 6-37) antibody

Details for Product No. ABIN392017
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Antigen
Synonyms C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2, MER, RP38, c-mer, Eyk, Mer, Nyk, nmf12, rdy
Epitope
N-Term, AA 6-37
(19), (11), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(85), (22), (17), (2)
Host
Rabbit
(63), (17), (7), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(69), (44), (21), (10), (9), (5), (5), (3), (2)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN392017
291.50 $
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Immunogen This MERTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-37 AA from the N-terminal region of human MERTK.
Clone RB01486
Isotype Ig
Specificity This MERTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14~44 amino acids from the N-terminal region of human MERK.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name MERTK
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Synonyms: Receptor tyrosine kinase MerTK, MERTK, MER
Molecular Weight 110390 DA
Gene ID 10461
UniProt Q12866
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.93 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (N-Term), (AA 6-37) antibody Western blot analysis of anti-MERK Pab (ABIN392017) in NIH/3T3 cell lysate. MERK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (N-Term), (AA 6-37) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with MERK antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Graham, Dawson, Mullaney et al.: "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 647-57, 1994 (PubMed).

Thompson, McHenry, Li et al.: "Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively." in: American journal of human genetics, Vol. 70, Issue 1, pp. 224-9, 2001 (PubMed).

Validation Images
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