You are viewing an incomplete version of our website. Please click to reload the website as full version.

PDGFRA antibody (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (AA 732-761)

Details for Product anti-PDGFRA Antibody No. ABIN392029, Supplier: Log in to see
Antigen
  • AI115593
  • CD140a
  • Pdgfr-2
  • APDGFR
  • PDGFACE
  • CD140A
  • PDGFR-2
  • PDGFR2
  • RHEPDGFRA
  • PDGFR
  • PDGFR-A
Alternatives
anti-Human PDGFRA antibody for Enzyme Immunoassay
Epitope
AA 732-761, Tyr754
50
26
19
19
18
17
16
15
15
13
13
13
13
12
11
11
9
7
6
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
377
176
126
4
3
3
3
3
2
1
1
1
1
1
1
Host
Rabbit
331
65
24
1
1
Clonality (Clone)
Polyclonal ()
Conjugate
This PDGFRA antibody is un-conjugated
29
24
24
22
19
14
7
5
5
5
5
5
5
5
5
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
247
173
143
69
59
57
35
21
14
10
9
5
4
3
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 732-761 AA from human PDGFRA.
Clone RB11213
Isotype Ig
Specificity This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y754 of human PDGFRA.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PDGFRA (PDGFRA Antibody Abstract)
Background PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Synonyms: PDGF-R-alpha, CD140a antigen, Alpha platelet-derived growth factor receptor
Molecular Weight 122669 DA
Gene ID 5156
NCBI Accession NP_006197
Research Area Stem Cells, Protein Modifications, Cell Structure, Cell Cycle
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PDGFRA antibody (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (AA 732-761) (ABIN392029) Western blot analysis of PDGFRA (arrow) using rabbit polyclonal PDGFRA Antibody (Y754...
Immunofluorescence (IF) image for anti-PDGFRA antibody (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (AA 732-761) (ABIN392029) Immunofluorescence analysis of anti-PDGFRA polyclonal antibody (ABIN392029) in HeLa c...
Immunohistochemistry (IHC) image for anti-PDGFRA antibody (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (AA 732-761) (ABIN392029) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PDGFRA...
Background publications Wilczynski, Chen, Chen et al.: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, 2005 (PubMed).

Debiec-Rychter, Cools, Dumez et al.: "Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants." in: Gastroenterology, Vol. 128, Issue 2, pp. 270-9, 2005 (PubMed).

Hiwatari, Taki, Tsuchida et al.: "Novel missense mutations in the tyrosine kinase domain of the platelet-derived growth factor receptor alpha(PDGFRA) gene in childhood acute myeloid leukemia with t(8;21)(q22;q22) or inv(16)(p13q22)." in: Leukemia, Vol. 19, Issue 3, pp. 476-7, 2005 (PubMed).

Sakurai, Hasegawa, Sakuma et al.: "Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene." in: Human pathology, Vol. 35, Issue 10, pp. 1223-30, 2004 (PubMed).

Subramanian, West, Corless et al.: "Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles." in: Oncogene, Vol. 23, Issue 47, pp. 7780-90, 2004 (PubMed).