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tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 383-411), (Center) antibody

Details for Product No. ABIN392084
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Antigen
Epitope
AA 383-411, Center
(23), (22), (12), (12), (10), (8), (7), (7), (7), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(141), (76), (63), (49), (49), (48), (12), (2)
Host
Rabbit
(139), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(89), (64), (40), (21), (21), (18), (12), (6), (5), (3), (3)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN392084
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Immunogen This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-411 AA from the Central region of human ACK1.
Clone RB15645
Isotype Ig
Specificity This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390~419 amino acids from the Center region of human ACK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACK1
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Synonyms: Tyrosine kinase non-receptor protein 2, Activated CDC42 kinase 1, ACK-1, ACK1, TNK2
Molecular Weight 114327 DA
Gene ID 10188
UniProt Q07912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 383-411), (Center) antibody Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (Center) (ABIN392084). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACK1 gene (Lane 2) (60 KD recombinant protein).
Background publications Manser, Leung, Salihuddin et al.: "A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42." in: Nature, Vol. 363, Issue 6427, pp. 364-7, 1993 (PubMed).

Yokoyama, Miller: "Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47713-23, 2003 (PubMed).

Validation Images
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