|+1 404 474 4654|
|+1 888 205 9894 (TF)|
tyrosine Kinase, Non-Receptor, 2 (TNK2) (Tyr80) antibody
Alternatives Western Blotting (WB), ELISA
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814~844 amino acids surrounding Y826 of human ACK1.|
|Description||Other names: Tyrosine kinase non-receptor protein 2, Activated CDC42 kinase 1, ACK-1, ACK1, TNK2|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814~844 amino acids surrounding Y826 of human ACK1.|
|Molecular Weight||114327 DA|
Background: ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Manser, Leung, Salihuddin et al.: "A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42." in: Nature, Vol. 363, Issue 6427, pp. 364-7, 1993 (PubMed).
Yokoyama, Miller: "Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47713-23, 2003 (PubMed).